Announcements and Notices - [Change in Company Secretary] CHANGE OF COMPANY SECRETARY, AUTHORIZED REPRESENTATIVE AND PROCESS AGENT

Constitutional Documents Tenth Amended and Restated Memorandum and Articles of Association

Announcements and Notices - [Results of AGM] POLL RESULTS OF THE ANNUAL GENERAL MEETING HELD ON JUNE 10, 2022

Announcements and Notices - [Other - Business Update] VOLUNTARY ANNOUNCEMENT - NMPA APPROVAL FOR REGISTRATION APPLICATION OF Fluxcap BALLOON GUIDE CATHETER

Monthly Returns Monthly Return of Equity Issuer on Movements in Securities for the Month ended 31 May 2022

Announcements and Notices - [Other - Business Update] VOLUNTARY ANNOUNCEMENT - NMPA APPROVAL FOR REGISTRATION APPLICATION OF Fastunnel DELIVERY BALLOON DILATION CATHETER

Announcements and Notices - [Other - Business Update] VOLUNTARY ANNOUNCEMENT - NMPA Approval for Registration Application of Tethys AS Aspiration Catheter

Proxy Forms FORM OF PROXY FOR THE ANNUAL GENERAL MEETING TO BE HELD ON JUNE 10, 2022

Announcements and Notices - [Notice of AGM / Closure of Books or Change of Book Closure Period] NOTICE OF ANNUAL GENERAL MEETING

Circulars - [Re-election or Appointment of Director subject to Shareholders' Approval / General Mandate / Explanatory Statement for Repurchase of Shares / Amendment of Constitutional Documents] PROPOSED GRANTING OF GENERAL MANDATES TO ISSUE SHARES AND REPURCHASE SHARES; PROPOSED RE-ELECTION OF RETIRING DIRECTORS; PROPOSED RE-APPOINTMENT OF AUDITOR; PROPOSED AMENDMENTS TO THE MEMORANDUM AND ARTICLES OF ASSOCIATION; AND NOTICE OF ANNUAL GENERAL MEETING

Announcements and Notices - [Amendment of Constitutional Documents] PROPOSED ADOPTION OF THE AMENDED AND RESTATED MEMORANDUM AND ARTICLES OF ASSOCIATION

Monthly Returns Monthly Return of Equity Issuer on Movements in Securities for the Month ended 30 April 2022

Monthly Returns Monthly Return of Equity Issuer on Movements in Securities for the Month ended 31 March 2022

Announcements and Notices - [Final Results] ANNUAL RESULTS ANNOUNCEMENT FOR THE YEAR ENDED DECEMBER 31, 2021

Announcements and Notices - [Date of Board Meeting] DATE OF BOARD MEETING

Monthly Returns Monthly Return of Equity Issuer on Movements in Securities for the Month ended 28 February 2022

Announcements and Notices - [Other - Business Update] VOLUNTARY ANNOUNCEMENT - NMPA Approval for Registration Application of Syphonet Stent Retriever

Monthly Returns Monthly Return of Equity Issuer on Movements in Securities for the Month ended 31 January 2022

Announcements and Notices - [Other - Trading Update] VOLUNTARY ANNOUNCEMENT - UNAUDITED OPERATING STATISTICS FOR THE PERIOD FROM JANUARY 1, 2021 TO DECEMBER 31, 2021

Announcements and Notices - [Other - Business Update] VOLUNTARY ANNOUNCEMENT - COLLABORATION AND LICENSE AGREEMENT FOR TRANSCATHETER AORTIC VALVE REPLACEMENT PRODUCTS FOR THE TREATMENT OF AORTIC REGURGITATION WITH JENAVALVE TECHNOLOGY, INC.

Monthly Returns Monthly Return of Equity Issuer on Movements in Securities for the Month ended 31 December 2021