Announcements and Notices - [Terms of Reference of the Nomination Committee] TERMS OF REFERENCE OF THE NOMINATION COMMITTEE ADOPTED BY THE BOARD ON 30 JUNE, 2025

Announcements and Notices - [List of Directors and their Role and Function] LIST OF DIRECTORS AND THEIR ROLES AND FUNCTIONS

Announcements and Notices - [Results of AGM / Change in Directors or of Important Executive Functions or Responsibilities / Change of Audit Committee Member] POLL RESULTS OF THE ANNUAL GENERAL MEETING HELD ON 30 JUNE 2025, APPOINTMENT OF INDEPENDENT NON-EXECUTIVE DIRECTORS, CHANGE IN COMPOSITION OF BOARD COMMITTEES AND RE-COMPLIANCE WITH RULE 3.27A OF THE LISTING RULES

Announcements and Notices - [List of Directors and their Role and Function] LIST OF DIRECTORS AND THEIR ROLES AND FUNCTIONS

Announcements and Notices - [Change in Directors or of Important Executive Functions or Responsibilities] RESIGNATION OF EXECUTIVE DIRECTOR

Announcements and Notices - [Notice of AGM / Closure of Books or Change of Book Closure Period] POSTPONEMENT AND CHANGE OF VENUE OF ANNUAL GENERAL MEETING AND CHANGE OF BOOK CLOSURE PERIOD

Announcements and Notices - [List of Directors and their Role and Function] LIST OF DIRECTORS AND THEIR ROLES AND FUNCTIONS

Announcements and Notices - [Change in Directors or of Important Executive Functions or Responsibilities / Notice of AGM] PASSING AWAY OF AN INDEPENDENT NON-EXECUTIVE DIRECTOR AND WITHDRAWAL OF ORDINARY RESOLUTION NO. 2(d) AT THE ANNUAL GENERAL MEETING

Announcements and Notices - [Other - Miscellaneous] VOLUNTARY ANNOUNCEMENT CESSATION TO ACT AS PRESIDENT (CHINA)

Monthly Returns Monthly Return of Equity Issuer on Movements in Securities for the month ended 31 May 2025

Next Day Disclosure Returns - [Others] Next Day Disclosure Return

Announcements and Notices - [Issue of Shares under a General Mandate] COMPLETION OF SUBSCRIPTIONS OF NEW SHARES UNDER GENERAL MANDATE

Announcements and Notices - [Issue of Shares under a General Mandate] SUBSCRIPTIONS OF NEW SHARES UNDER GENERAL MANDATE

Monthly Returns Monthly Return of Equity Issuer on Movements in Securities for the month ended 30 April 2025

Circulars - [Other] Notification Letter to Non-registered Shareholders and Reply Form

Circulars - [Other] Notification Letter to Registered Shareholders and Reply Form

Announcements and Notices - [Notice of AGM / Closure of Books or Change of Book Closure Period] NOTICE OF 2025 ANNUAL GENERAL MEETING

Proxy Forms FORM OF PROXY FOR THE ANNUAL GENERAL MEETING TO BE HELD AT ROOM 3, 14/F, FAIRMONT HOUSE, 8 COTTON TREE DRIVE, CENTRAL, HONG KONG ON FRIDAY, 13 JUNE 2025 AT 10:00 A.M.

Circulars - [Re-election or Appointment of Director subject to Shareholders' Approval / Explanatory Statement for Repurchase of Shares / General Mandate] PROPOSED RE-ELECTION OF RETIRING DIRECTORS AND PROPOSED GRANTING OF GENERAL MANDATES TO BUY BACK SHARES AND TO ISSUE SHARES AND NOTICE OF ANNUAL GENERAL MEETING

Announcements and Notices - [Inside Information] INSIDE INFORMATION POSITIVE TOPLINE RESULTS FROM PHASE 1B CLINICAL TRIAL OF SM17 IN CHINA FOR THE TREATMENT OF MODERATE-TO-SEVERE ATOPIC DERMATITIS

Monthly Returns Monthly Return of Equity Issuer on Movements in Securities for the month ended 31 March 2025

Announcements and Notices - [Final Results / Dividend or Distribution / Closure of Books or Change of Book Closure Period / Modified Report by Auditors] ANNUAL RESULTS ANNOUNCEMENT FOR THE YEAR ENDED 31 DECEMBER 2024; AND CHANGE IN USE OF PROCEEDS

Announcements and Notices - [Date of Board Meeting] DATE OF BOARD MEETING

Monthly Returns Monthly Return of Equity Issuer on Movements in Securities for the month ended 28 February 2025

Monthly Returns Monthly Return of Equity Issuer on Movements in Securities for the month ended 31 January 2025

Monthly Returns Monthly Return of Equity Issuer on Movements in Securities for the month ended 31 December 2024